St. Jude Children's Research Hospital seeks a Scientist or Senior Scientist to join our Center for Advanced Genome Engineering (CAGE).

The World’s Brightest Minds Always Innovate

At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities, state-of-the-art technologies, and extraordinary support for your research to ensure scientific progress is never halted from a lack of resources. At St. Jude, you will be part of a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve.

This is an exciting opportunity for a Scientist or Senior Scientist to join our Center for Advanced Genome Engineering (CAGE).

The CAGE has three missions:

1) facilitate investigator-initiated genome editing projects using CRISPR-Cas9

2) perform independent R&D to evaluate and develop new genome editing techniques

3) to assist the gene and cell therapy programs at St. Jude Children’s Research Hospital.

The Shondra Pruett-Miller laboratory offers a strong team-based environment where you will work collaboratively with other investigators across the institution to support their research needs and develop and improve genome engineering technologies.

In this position, you will lead the Custom CRISPR Library service. You will stay up to date on current CRISPR screening technologies and adapt and incorporate them into current workflows to aid St. Jude investigators with their research. Duties will also include designing, cloning, and analyzing CRISPR libraries designed for knockout, inhibition, and activation screens. You will help fellow team members with their own designs and analyses. Your experience will also be used for developing and implementing bioinformatic workflows which aid CAGE lab members in CRISPR design and NGS analysis.

Successful candidates should display competencies in the following areas:

• Understanding of and experience with molecular biology techniques including DNA and RNA extractions, PCR, and plasmid cloning
• In depth knowledge and experience with CRISPR screens and analysis
• Excellent verbal and written communication skills
• Creative and self-motivated
• Experience with programming in python or other coding language is a plus
• Experience with liquid handling robots a plus
• Comfortable in a Linux environment and working on a cluster
• Comfortable working independently and as part of a team
• Ability to prioritize work based on need
• Ability to track and execute multiple projects at once
• Experience with Next-Generation Sequencing analysis is a plus

Minimum Education and/or Training:

• Bachelor's degree in relevant scientific area is required.

Minimum Experience:

Senior Scientist:

• Ten (10) years relevant post-degree work experience is required with a Bachelor's degree
• Eight (8) years of relevant post-degree work experience is required with a Master's degree
• Six (6) years of relevant post-degree work experience is required with a PhD

Compensation

In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of Senior Scientist Opportunity in St. Jude's Center for Advanced Genome Engineering.

Scientist:

• Seven (7) years of relevant post-degree work experience is required with a Bachelor's degree.
• Five (5) years of relevant post-degree work experience is required with a Master's degree.
• Three (3) years of relevant post-degree work experience is required with a PhD.

Compensation

In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $86,320 - $154,960 per year for the role of Scientist / Senior Scientist Opportunity in St. Jude's Center for Advanced Genome Engineering.

Explore our exceptional benefits!

Diversity, Equity and Inclusion

St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay. Learn more about our history and commitment.

Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital’s roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.

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