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Memphis, TNPOSTDOCTORAL RESEARCH ASSOCIATE - SURGERY
Memphis, TN
POSTDOCTORAL RESEARCH ASSOCIATE - SURGERY
Memphis, TNThe World’s Most Dedicated Never Give Up
There’s a reason St. Jude Children’s Research Hospital is recognized as a great place to work. Because at our world-class pediatric research hospital, every one of our professionals shares our commitment to make a difference in the lives of the children we serve. There’s a unique bond when you’re part of a team that gives their all to advance the treatments and cures of pediatric catastrophic diseases. The result is a collaborative, positive environment where everyone, regardless of their role, receives the resources, support and encouragement to advance and grow their careers and be the force behind the cures.
The research focuses on understanding and targeting epigenetic and splicing factors in high-risk neuroblastoma. This work is highly mechanistic and translational, leveraging cutting-edge genetic, epigenomic, and pharmacologic tools in patient-derived xenografts and genetically engineered mouse models to inform better therapies.
Key Responsibilities
Design and conduct experiments investigating the role of epigenetic regulators in regulating therapy resistance.
Utilize molecular, cellular, and biochemical techniques including CRISPR, RNA-seq, CUT&RUN, ATAC-seq, HiC, flow cytometry, and 3D tumor modeling.
Analyze how epigenetic modulation alters chromatin states and cell state transitions.
Evaluate preclinical efficacy of molecular glue drugs in combination with standard therapies.
Collaborate within a multidisciplinary team including cancer biologists and clinicians.
Present findings at national and international meetings and contribute to manuscript preparation and grant proposals.
Qualifications
A Ph.D. (or nearing completion) in molecular biology, cancer biology, biochemistry, developmental biology, immunology, or related fields.
Strong background in epigenetics, transcriptional regulation, or chromatin biology is highly desirable.
Experience with mouse models, genome editing, or next-generation sequencing is a plus.
Excellent communication skills, critical thinking, and a collaborative mindset.
A strong publication record demonstrating scientific rigor and productivity.
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