ASSOCIATE SCIENTIST - JONATHAN YEN LAB (THERAPEUTIC GENOME ENGINEERING, HEMATOPOIETIC STEM CELL BIOLOGY AND MOLECULAR BIOLOGY)

Memphis, TN

The World’s Most Dedicated Never Give Up

There’s a reason St. Jude Children’s Research Hospital is recognized as a great place to work. Because at our world-class pediatric research hospital, every one of our professionals shares our commitment to make a difference in the lives of the children we serve. There’s a unique bond when you’re part of a team that gives their all to advance the treatments and cures of pediatric catastrophic diseases. The result is a collaborative, positive environment where everyone, regardless of their role, receives the resources, support and encouragement to advance and grow their careers and be the force behind the cures.

An Associate Scientist performs a variety of moderately complex research tasks determined by the field and scope of the particular research project/study. Performs tasks related to the research project independently, but within broad guidelines and subject to periodic review by supervisor or other research staff.

We are seeking outstanding, highly motivated, and creative candidates for an Associate Scientist role in Dr. Jonathan Yen's lab and Therapeutic Genome Engineering (TGEn) group that is part of a multidisciplinary team of scientists and clinical researchers to help advance genome editing strategies to treat sickle cell disease to a Phase 1 clinical trial. Our ongoing therapeutic pipeline is fueled by internal scientific discoveries directed from “bench-to-bedside” and academic collaborations.

You will have the opportunity to work with a talented interdisciplinary team of scientists to develop a cellular therapy with the goal of treating patients here at St. Jude Children's Research Hospital and worldwide. The ideal candidate will have a combination of experience with genome editing and human hematopoietic stem cells.

Job Responsibilities:

Perform studies to develop genome editing strategies for human hematopoietic stem cells (HSC). 
Design and execute IND-enabling experiments to characterize the pharmacology of a genome-edited human hematopoietic stem cell product to treat sickle cell disease. 
Characterize the efficacy, safety, and potency of the HSC cellular drug product in in vitro and xenotransplantation assays. 
Processing of primary bone marrow and peripheral blood samples, including multicolor flow cytometry and FACS to sort hematopoietic populations of relevance.
Interact and collaborate with multidisciplinary teams to advance the program. 
NGS libraries preparation and analysis of editing outcomes, on-target and off-target.
Develop experimental methods including RT-PCR,  ddPCR, next-generation sequencing, and single-cell sequencing.
Establish tracking and trending analyses of process development and pilot runs.
Draft documentation (protocols, batch records, reports) to standardize and transfer process to GMP facility. 
Maintains regular and predictable attendance.
Performs other related duties as assigned in order to meet the goals of the department and institution.

Minimum Education and/or Training:

Bachelor’s degree in a relevant scientific area.
Master’s or PhD degree in relevant scientific area is highly preferred.

Minimum Experience:

7 + years of research experience is required.
5 + years of research experience is required with a Master’s degree.
2 + years of research experience is required with a PHD.
Experience leading and supporting research experiments preferred.
Some experience leading lab and scientific project coordination, maintenance, and other research support activities preferred.
Experience in guiding and training other laboratory personnel preferred.
Proven performance in earlier role/comparable role.

Compensation

In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $65,520 - $114,400 per year for the role of Associate Scientist - Jonathan Yen Lab (Therapeutic Genome Engineering, Hematopoietic Stem Cell Biology and Molecular Biology).

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St. Jude is an Equal Opportunity Employer

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