The Protein Technologies Center (PTC) is seeking a highly motivated protein biochemist or molecular biologist who is interested in determining the atomic-level structures of proteins to better comprehend how they contribute to important biological processes.

The PTC is a multidisciplinary team with expertise in structural biology workflow and biophysics. The PTC works with several investigators in the department and across the hospital and is responsible for cloning, construct optimization, protein purification, biophysical studies and structure elucidation. This job is a bench-based scientist role where you will conduct experiments, interact closely with other scientists and investigators, and participate in collaborative research toward understanding the basis of disease.

Responsibilities:

• The selected candidate will use their molecular biology, biochemistry, or structural biology skills, to design constructs, and purify proteins for structural studies and biophysical characterization. 
• Work with several labs and guide structural biology efforts using crystallography and/or cryo-EM technologies.
• Able to troubleshoot protein expression and purification problems. 
• Interpret, analyze, and communicate structural biology results with collaborators.
• Prioritize work and complete assignments in a timely fashion.
• Train and mentor research associates, students, and/or postdoctoral associates who seek to leverage the Protein Technologies Center’s capabilities at St. Jude.

Minimum Education and/or Training:

• Bachelor's degree in relevant scientific area is required.
• PhD in the area of molecular biology, biochemistry, protein engineering, or any related discipline preferred.

Minimum Experience:

• Eight (8) years of relevant work experience is required with a Bachelor's degree.
• Six (6) years of relevant work experience is required with a Master's degree.
• Three (3) years of relevant work experience is required with a PhD.

Additional preferred skills:

• Experience in sample preparation for both negative-stain and single particle EM, data collection, data processing and model building.
• Demonstrated ability to purify challenging macromolecules and/or complexes (e.g. membrane proteins, viral glycoproteins, antibody-antigen complexes etc.).

Compensation

In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $86,320 - $154,960 per year for the role of Scientist - Protein Technology Center.

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St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay. Learn more about our history and commitment.

Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital’s roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.

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