Senior Bioinformatics Research Scientist/Bioinformatic Research Scientist

Memphis, TN

About St. Jude Children's Research Hospital

The World’s Most Dedicated Never Give Up

There’s a reason St. Jude Children’s Research Hospital is recognized as a great place to work. Because at our world-class pediatric research hospital, every one of our professionals shares our commitment to make a difference in the lives of the children we serve. There’s a unique bond when you’re part of a team that gives their all to advance the treatments and cures of pediatric catastrophic diseases. The result is a collaborative, positive environment where everyone, regardless of their role, receives the resources, support and encouragement to advance and grow their careers and be the force behind the cures.

Senior Bioinformatics Research Scientist/Bioinformatic Research Scientist

The Center for Applied Bioinformatics (CAB) is looking for a highly motivated and creative individual to join our Genetics Group. As a Senior Bioinformatics Scientist/Bioinformatic Research Scientist (Statistical Genetics/Genetic Epidemiology), your responsibilities will include genotype-phenotype association, ancestry inference, QC and development/testing of analytic pipelines for familial and population genetics projects. We are seeking candidates with expertise in identifying causal or susceptibility factors (including genetic, epigenetic and environmental factors) that increase disease risk or modify disease progression, treatment responsiveness, and survivorship. We have ongoing sequencing projects in pediatric cancer and neurological diseases. There are opportunities to work on ongoing GWAS and sequencing projects as well develop new projects in areas such as statistical methods for genetic studies. We are particularly interested in individuals with experience in any of the following : working with large public genomic databases, statistical and bioinformatic fine-mapping approaches, pathway analysis, predictive modeling.


We are closely integrated with the Transcriptomics and Epigenetics Groups in the CAB, allowing for cross-training opportunities and collaboration. Additionally, we are supported by a Development and Operations team with computational expertise in transferring base developmental pipelines into streamline/high throughput pipelines. Our group works closely with investigators in St. Jude Children’s Research Hospital Comprehensive Cancer Center, the first and only NCI designated cancer center devoted to children (, in order to discover and understand the genetics and biology of pediatric cancers. Our projects extend to nonmalignant hematological disorders such as the Sickle Genome Project ( and related blood  disorders (  and neurological diseases. We have close collaboration with the Department of Biostatistics ( for expanding methodological approaches.

Applicants should have training in statistical genetics, genetic epidemiology, or bioinformatics with in-depth understanding of computational genomics and disease modeling tools, including association and rare variant methods. Experience with data assimilation across WGS, RNAseq, and ChIPSeq datasets is desirable. Should be familial with public genomics datasets such as 1000G, gnomAD, TopMed, dbGAP, GTXe Portal.

Substantial skills in computer programming, including R or Python, are required. Java web development skills is desirable.

• Assist with preparation of project reports, presentations, and manuscript of analysis results, including detailed description of statistical genetic methods

• Participate in the development of operations and procedures for the collection, editing, verification and management of data.

• Run existing routine pipelines for germline SNV/Indel and CNV rare variant pathogenicity classification

Senior Bioinformatic Research Scientist

  • Minimum Requirement: Bachelor's degree with 7+ years of relevant post-degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry).
  • Experience Exception: Master's degree with 5+ years of relevant post-degree experience (OR) PhD with 2+ years of relevant post-degree experience.
  • Significant experience in at least one programming or scripting language and at least one statistical package, with R preferred.


Bioinformatic Research Scientist

  • Bachelor's degree with 4+ years of relevant post-degree work experience (OR) Master's degree with 2+ years of experience (OR) PhD with no work experience in relevant area (e.g., bioinformatics, cheminformatics, statistics/computer science with a background in biological sciences or chemistry).
  • Experience in at least one programming or scripting language and at least one statistical package, with R preferred.