Synthetic Organic Chemist: Fluorescent Probes

Memphis, TN

About St. Jude Children's Research Hospital

The World’s Most Dedicated Never Give Up

There’s a reason St. Jude Children’s Research Hospital is consistently ranked on Fortune Magazine’s “100 Best Places to Work For” list. Because at our world-class pediatric research hospital, every one of our professionals shares our commitment to make a difference in the lives of the children we serve. There’s a unique bond when you’re part of a team that gives their all to advance the treatments and cures of pediatric catastrophic diseases. The result is a collaborative, positive environment where everyone, regardless of their role, receives the resources, support and encouragement to advance and grow their careers and be the force behind the cures.

Synthetic Organic Chemist: Fluorescent Probes

St. Jude Children’s Research Hospital is one of the world’s premier research and treatment centers for pediatric cancer and other life-threatening diseases. It is globally recognized for its pioneering work in pediatric oncology and hematology; genomics; computational biology; immunology; infectious diseases; cell, molecular and structural biology; neurobiology; drug discovery; and global medicine.

St. Jude Children’s Research Hospital has a unified mission to use cutting-edge research to discover the origins of disease, especially cancer, in order to facilitate advances in the treatment to improve the lives of patients. The Department of Structural Biology is seeking a synthetic organic chemist to lead chemistry initiatives in Dr. Scott Blanchard’s lab to further develop intra-molecular photo-stabilized fluorescent probes for imaging applications. Qualified applicants will also lead chemical biology initiatives aimed at advancing the mechanistic study of clinically important biological systems at the single-molecule scale. The highly collaborative, hypothesis-driven environment requires a team-oriented individual with strong leadership skills to ensure quality operations as well as the vision and creativity to successfully pursue scientific advances.

Preferred Skills

  • Experience designing and performing multiple-step synthesis from commercially available reagents.
  • Experience in troubleshooting and optimizing chemical reactions and purification techniques.
  • Experience with moisture-sensitive reactants, conventional chromatographic methods, HPLC purification, LC-MS, and NMR.
  • Basic knowledge in fluorophore design and good understanding in fluorophore structure -performance relationships.
  • Ability to carry out multiple projects and responsibilities in parallel, delegating as appropriate.
  • Expert ability to distill complex information in a clear and concise manner both verbally and in writing.
  • Design and synthesis of Cyanine- and Rhodamine-class organic fluorophores and other bio-active small molecules.
  • Methodology development and yield optimization for improved syntheses and scaling.
  • Presentation of experimental data, research progress for collaborative publications.
  • Effectively communicate and help advance multidisciplinary team-based research projects.
  • Safety guidelines, chemical management, and maintenance of laboratory equipment.
  • Bachelor's degree in relevant scientific area is required.

Scientist

  • Seven (7) years of relevant post-degree work experience is required.
  • Five (5) years of relevant post-degree work experience is required with a Master's degree.
  • Three (3) years of relevant post-degree work experience is required with a PhD.

 Lead Researcher

  • Five (5) years of relevant, post-degree work experience is required with a Bachelor's degree.
  • Two (2) years of relevant post-degree work experience is required with a Master's degree.
  • No experience is required with a PhD degree.

COVID-19 vaccine:

As of September 10, 2021, St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.

EEO Statement:  St. Jude is an Equal Opportunity Employer

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