Lead Researcher - Yu Lab of Systems Biology

Memphis, TN

About St. Jude Children's Research Hospital

The World’s Most Dedicated Never Give Up

There’s a reason St. Jude Children’s Research Hospital is consistently ranked on Fortune Magazine’s “100 Best Places to Work For” list. Because at our world-class pediatric research hospital, every one of our professionals shares our commitment to make a difference in the lives of the children we serve. There’s a unique bond when you’re part of a team that gives their all to advance the treatments and cures of pediatric catastrophic diseases. The result is a collaborative, positive environment where everyone, regardless of their role, receives the resources, support and encouragement to advance and grow their careers and be the force behind the cures.

Lead Researcher - Yu Lab of Systems Biology

The Yu Lab in the Department of Computational Biology is seeking outstanding candidates for a leader researcher focused on systems chemical biology and drug discovery. The Yu Lab is focused on developing and applying computational and systems biology approaches to dissect the molecular circuits that drive tumorigenesis, tumor immune-escape and drug resistance, and identifying novel immunotherapy targets, biomarkers and combination therapies (particularly with immunotherapy) for the treatment of pediatric cancers. This lead researcher will lead the efforts of preclinical target validation, compound screening and optimization, and mechanism of action studies. This lead researcher will assist to analyze and integrate high-throughput omics data, at bulk and single-cell levels, including transcriptomic, genomic, epigenomic, functional genomic, chemical genomic and proteomic data to model context-specific cellular/molecular networks and to identify actionable targets, biomarkers or compounds that could be translated into clinic for the development of precision medicine in pediatric cancer. The candidate will work closely with our collaborators in the departments of iTARGETS, Immunology, Chemical Biology, and Oncology for experiment design and data generation, and with our pipeline and visualization teams to explore novel analysis approaches for drug screening, single-cell RNA-Seq, NGS-based RNAi/CRISPR screening, immune-profiling and proteomics data for molecular network inference and target identification.

Candidates with a strong interest in cancer immunotherapy, cancer precision medicine and expertise in chemical biology, oncology, immunology, computational biology, bioinformatics are encouraged to apply. The successful candidate will also have an opportunity to participate in research projects involved in the analysis of the cancer genome, epigenome, transcriptome or proteome. Experience with omics data analysis using R or Python and familiarity with linux/unix is preferred. Experience and knowledge in chemical biology, immunology and/or immuno-oncology is highly desirable. Expertise in systems biology, network biology, parallel computing, web development, visualization and databases is also highly desirable.

The Yu Lab provides a highly interactive environment with projects involving basic and clinical research collaborators, access to high performance computing clusters, cloud computing environment, innovative visualization tools, highly automated analytical pipelines and teamwork with scientists who have deep experience in data analysis, data management and delivery of high-quality results for highly competitive projects. As a member in Yu Lab, you will interact with leaders in cancer and translational research within and outside the institution and at national/international meetings. Innovative research will be supported by the lab’s infrastructure, which includes a wet-lab component. Lab members have considerable flexibility and freedom to develop their research programs.

St. Jude provides a highly interactive and supportive environment for researchers’ career development and has been named to Glassdoor’s Best Places to Work 2018. St. Jude is a top-ranked hospital (#1 for pediatric cancer specialty in the U.S. in 2017) and a world-class basic research institute with 260+ faculty members.

  • Bachelor's degree in relevant scientific area is required
  • Five (5) years of relevant, post-degree work experience is required
  • Two (2) years of relevant post-degree work experience is required with a Master's degree
  • No experience is required with a PHD
St. Jude is an Equal Opportunity Employer

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