Lead Bioinformatics Analyst
About St. Jude Children's Research Hospital
The World’s Most Dedicated Never Give Up
There’s a reason St. Jude Children’s Research Hospital is consistently ranked on Fortune Magazine’s “100 Best Places to Work For” list. Because at our world-class pediatric research hospital, every one of our professionals shares our commitment to make a difference in the lives of the children we serve. There’s a unique bond when you’re part of a team that gives their all to advance the treatments and cures of pediatric catastrophic diseases. The result is a collaborative, positive environment where everyone, regardless of their role, receives the resources, support and encouragement to advance and grow their careers and be the force behind the cures.
Lead Bioinformatics Analyst
The Mefford Lab in the Center for Pediatric Neurological Disease Research at St. Jude Children’s Research Hospital uses genome-wide approaches to identify genetic, genomic, and epigenetic causes of human disease including epilepsy, and related pediatric neurodevelopmental disorders. The major focus of our current work is to identify causes of pediatric epilepsy by employing state-of-the-art technologies including whole-exome sequencing, targeted gene panel sequencing, RNA-seq in patient-derived cells, genome-wide methylation arrays. The Mefford lab has discovered numerous new epilepsy genes and copy number variants responsible for pediatric epilepsy, each of which causes a range of clinical features.
The Lead Bioinformatics Analyst will take a prominent role in our research and collaborations to analyze multiple types of genomics data: exome and genome sequence, bulk RNA-seq, single-cell/nuclei RNA-seq, methylation, SNP array, and others to identify variants associated with human genetic conditions and understand their underlying mechanisms. The ideal candidate will be capable of self-directed research within broader goals set by the group, have previous experience with next-generation sequence data analysis highly desirable, knowledge of statistical/mathematical packages such as R.
As of September 10, 2021, St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.
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